PyOphidia provides the Python bindings for Ophidia, a High-Performance Data Analytics framework. PyOphidia provides the Python bindings for the Ophidia framework, an open-source solution for the analysis of scientific multi-dimensional data, joining HPC paradigms and Big Data approaches. It provides an environment targeting High Performance Data Analytics through parallel and in-memory data processing, data-driven task scheduling and server-side analysis. The framework supports the execution of complex analytics workflows in the form of DAGs of Ophidia operators. The PyOphidia module brings HPDA capabilities within the scientific Python ecosystem through a high-level interface that allows handling distributed datasets, running parallel analysis and interacting with High Performance Computing (HPC) infrastructures.